In cross population analyses (n=52), sample median 24 hour sodium excretion higher by 100 mmol was associated with median systolic/diastolic pressure higher on average by 5 7/2 4 mm Hg, and estimated mean difference in systolic/diastolic pressure at age 55 compared with age 25 greater by 10 11/6 mm Hg.Conclusions: The strong, positive association of urinary sodium with systolic pressure of individuals concurs with Intersalt cross population findings and results of other studies. Higher urinary sodium is also associated with substantially greater differences in blood pressure in middle age compared with young adulthood. These results support recommendations for reduction of high salt intake in populations for prevention and control of adverse blood pressure levels.Key messagesThe within population findings were previously underestimated because of incomplete correction for the regression dilution problemRevised estimates of the within population association of sodium to blood pressure in Intersalt are concordant with the cross population findings for 52 samplesEstimates of the effect of median sodium excretion higher by 100 mmol/day over a 30 year period (age 55 minus age 25) were a greater difference of 10 11 mm Hg in systolic blood pressure and 6 mm Hg in diastolic blood pressureThese results lend further support to recommendations for mass reduction of high salt intake for the prevention and control of adverse blood pressure levels and high blood pressure in populationsIn 1988, the Intersalt study published results showing a highly significant positive relation between 24 hour urinary sodium excretion and systolic blood pressure.

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